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KMID : 0191120130280091403
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Journal of Korean Medical Science
2013 Volume.28 No. 9 p.1403 ~ p.1406
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Association of the Catechol-o-Methyltransferase Gene Polymorphisms with Korean Autism Spectrum Disorders
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Yoo Hee-Jeong
Cho In-Hee
Park Mi-Ra
Yang So-Young
Kim Soon-Ae
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Abstract
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This study evaluated the family-based genetic association between autism spectrum disorders (ASDs) and 5 single-nucleotide polymorphisms (SNPs) in the catechol-o-methyltransferase gene (COMT), which was found among 151 Korean ASDs family trios (dominant model Z = 2.598, P = 0.009, PFDR = 0.045). We found a statistically significant allele transmission or association in terms of the rs6269 SNP in the ASDs trios. Moreover, in the haplotype analysis, the haplotypes with rs6269 demonstrated significant evidence of an association with ASDs (additive model rs6269-rs4818-rs4680-rs769224 haplotype P = 0.004, PFDR = 0.040). Thus, an association may exist between the variants of the COMT gene and the occurrence of ASDs in Koreans.
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KEYWORD
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Autism Spectrum Disorders (ASD), Polymorphisms, Single Nucleotide (SNPs), Catechol-O-Methyltransferase Gene (COMT), Family-Based Association Study
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